There is no debate in one area that the transplanted bone marrow cells are rejuvenating hearts.
According to Joshua Hare MD; a Hopkins University cardiologist on the board of Institute for Cell Engineering.
"Millions of dollars and years of effort can be spent trying to pin down the minutiae of stem cell science when patients need help immediately! Basic scientists say it is premature to do the trials when the mechanisms are unknown, "But I say it's unethical to wait." "Now it is possible to isolate adult stem cells and differentiate them in vitro into actual beating heart cells; that may be reinfused fairly easily back into the donor patient."
Dr, Joshua Hare MD Johns Hopkins - Institute for Cell Engineering , http://heart.sdsu.edu/~website/IRRI/Pages/faculty/untitled-2.html
In cardiology neocardiogenesis is the homeostatic regeneration, repair and renewal of sections of malfunctioning adult cardiovascular tissue. This includes a combination of cardiomyogenesis (the regeneration of cardiac muscle) and angiogenesis (the regeneration of blood vessels).
Definition and Scope
The term neocardiogenesis comes from cardiogenesis, which refers to the development of the heart in the embryo; neocardiogenesis, in turn, means the development of the heart in adults. The heart has mechanisms already in place that are responsible for small scale repair. However, these repair mechanisms are not sufficient for large scale repair, made necessary by events such as myocardial infarctions. Neocardiogenesis replaces dead cardiac muscle cells with living cells so that both the structure and function of the heart are maintained. This improves myocardial pumping of fluid around the body.
Dr. David A. Wolf MD Chief NASA Astronaut , https://www.jsc.nasa.gov/Bios/htmlbios/wolf.html%20
Stem Cell News
The recently completed Human Genome Project, determined the sequence of DNA in the human genome (each species has its own), lists about 25,000 genes. Added together the human genome contains over 3 billion chemical letters. If all the letters in the genome of a single stem cell were put on paper, the amount of information would fill one and a half million pages.
The interplay between genes and proteins lies behind many, if not most, illnesses. Thousands of disorders, such as cystic fibrosis, sickle cell anemia, and Huntington’s disease, result from a single defective or mutated gene, making a dysfunctional protein.
Global interest in report co-authored by members of ISCT Presidential Task Force on UCT
Friday, July 7, 2017
Commercial promotion of unsupported therapeutic uses of stem cells is a global problem that has proven resistant to regulatory efforts. Here, we suggest a coordinated approach at the national and international levels focused on engagement, harmonization, and enforcement to reduce the risks associated with direct-to-consumer marketing of unproven stem cell treatments.
ISCT is a global society of clinicians, regulators, technologists, and industry partners with a shared vision to translate cellular therapy into safe and effective therapies to improve patients' lives. ISCT Members gain access to an influential global community of peers, experts, and organizations invested in cell therapy. ISCT offers a unique collaboration between academia, regulatory bodies, and industry partners in cell therapy translation. Join us today!
John EJ Rasko PhD, President International Society for Cellular Therapy, http://www.celltherapysociety.org/
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